Granulation and hot melt extrusion (HME) are two techniques used in pharmaceutical manufacturing to create desired particle characteristics for tablets, capsules, and other dosage forms. 

• Granulation is a process that converts fine drug powders into larger, uniform granules to improve flowability, content uniformity, and tableting performance.
• Hot melt extrusion (HME) involves melting a drug substance with a carrier material and forcing the mixture through a die to create a continuous strand that is then cooled and milled into granules. HME is particularly useful for improving the bioavailability of poorly soluble drugs.

Hot melt extrusion (HME) involves melting a drug substance with a carrier material and forcing the mixture through a die to create a continuous strand that is then cooled and milled into granules. HME is particularly useful for improving the bioavailability of poorly soluble drugs.